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Friday, July 31, 2020 | History

1 edition of Predictive and prognostic information in the diagnosis and treatment of cancer found in the catalog.

Predictive and prognostic information in the diagnosis and treatment of cancer

Predictive and prognostic information in the diagnosis and treatment of cancer

helping patients utilize information for shared decision making

  • 339 Want to read
  • 38 Currently reading

Published by Leonard Mafrica, on behalf of the Oncology Nursing Society in [Pittsburg, Pa.] .
Written in English


Edition Notes

Statementeditor, Margaret Quinn Rosenzweig ; authors, Margaret Quinn Rosenzweig ... [et al.].
ID Numbers
Open LibraryOL16223398M

To be able to select the patients, prognostic and predictive markers are needed. Prognostic biomarkers provide information about the patient’s overall cancer outcome, regardless of the therapy. Predictive biomarkers give information about the effect of a therapeutic intervention [1–3]. Our findings indicate that plasma miR and let-7f are biomarkers for ovarian cancer detection that complement CA; let-7f may be predictive of ovarian cancer prognosis. View Show abstract.

Get this from a library! Methods of cancer diagnosis, therapy and prognosis: breast carcinoma. [M A Hayat;] -- This is the first book that discusses subjects of diagnosis, therapy, therapy assessment, and prognosis of breast cancer in one single volume. Cancer killed million people around the world in. Among prognostic surface markers detected by flow cytometry or immunohistochemistry, CD49d is independent ofFISHandIGHV. 17 Del(17p) andTP53mutations are currently the only disease-based predictive markers that affect treatment selection in CLL. With changing treatment options, the value of other prognostic markers continues to evolve.

A prognostic factor is an aspect of the cancer or a characteristic of the person (such as sex) that the doctor will consider when making a prognosis. A predictive factor influences how a cancer will respond to a certain treatment. Prognostic and predictive factors are often discussed together. Prognostic and Predictive Markers in Breast Cancer: Immunophenotypic and Genotypic Analyses The role of the pathologist in the evaluation of breast cancer now transcends that of determining the correct morphologic diagnosis, including the grading and staging of the cancer. Breast oncologists increasingly make treatment decisions.


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Predictive and prognostic information in the diagnosis and treatment of cancer Download PDF EPUB FB2

A prognostic biomarker informs about a likely cancer outcome (eg, disease recurrence, disease progression, death) independent of treatment received.

Examples of prognostic biomarkers are PSA level at the time of a prostate cancer diagnosis or the PIK3CA mutation status of tumors in women with human epidermal growth factor receptor 2 (HER2 Cited by:   Biomarkers can be diagnostic (determine the presence and type of cancer), prognostic (give information on the patient's overall cancer outcome with or without standard treatment), or predictive (help to identify which treatment the patient is most likely to respond to or benefit from).

Certain biomarkers can be diagnostic, prognostic, and Author: Jason Y.H. Chang, Sylvain Ladame. Prognostic Factors in Cancer, Third Edition examines the prognostic factors associated with each cancer site and provides insight into potential treatments and therapies.

The text is an extension of the International Union Against Cancer's (UICC) seminal work, the TNM Classification of Malignant Tumours, and integrates the current focus on prognostics in cancer. Major advances in cancer control will be greatly aided by early detection for the diagnosis and treatment of cancer in its pre-invasive state.

Cancer being a diverse disease involves alterations in three classes of genes viz. (proto) oncogenes, tumour suppressor genes and DNA repair genes offering a wide variety of opportunities for the. The discovery of new biomarkers would bring great benefits to patients because more accurate bio-pathological characterizations would allow better treatment and follow-up decisions.

Our purpose is to provide the salient information on various tissue biomarkers for the early diagnosis, treatment and prognosis of gastric : Vincenzo Canzonieri, Vincenzo Canzonieri, Federica Rao, Tiziana Perin, Lara Alessandrini, Angela Buo.

The Prostate Cancer Research International Active Surveillance (PRIAS) study showed that, in addition to age and PSA at diagnosis, both PSA density (PSA-D) and the number of positive cores at diagnosis (two compared with one) are the strongest predictors for reclassification biopsy or switching to deferred treatment.

Researchers study genes to help them learn more about which ones may be linked to cancer. They have mapped all of the genes that make up humans (called the human genome).

Doctors are now using the human genome and better gene-based tests to study DNA and better understand cancer. A widely acclaimed guide for cancer patients and their families, Understanding Cancer is also an immensely helpful read for basic cancer scientists who wish to broaden their perspectives on cancer and appreciate the potential impact of their research.

This book is part of the National Cancer Institute’s TASC (Take a Scientist to the Clinic) seminar series. Purpose: We aimed to develop an ovarian cancer-specific predictive framework for clinical stage, histotype, residual tumor burden, and prognosis using machine learning methods based on multiple biomarkers.

Experimental design: Overall, patients with epithelial ovarian cancer (EOC) and patients with benign ovarian tumors were randomly assigned to "training" and "test" cohorts. Zhao, F. et al. Sites of synchronous distant metastases and prognosis in prostate cancer patients with bone metastases at initial diagnosis: a population-based study.

Bladder cancer still requires improvements in diagnosis and prognosis, because many of the cases will recur and/or metastasize with bad outcomes. Despite ongoing research on bladder biomarkers, the clinicopathological impact and diagnostic function of miRNA maturation regulators Drosha and Argonaute proteins AGO1 and AGO2 in urothelial bladder.

Patent US examined miR signatures in ovarian cancer to determine prognostic, diagnostic and predictive options. Patent US generated miR-based methods for ovarian cancer diagnosis and treatment. Patent US investigated methods for predicting and improving a chemotherapy response to treat ovarian cancer.

Introduction. The new high-throughput “omics” technologies have recently opened the possibility to identify molecular changes and metabolic pathways in each cancer type with the possibility of molecular tumor subclassification and identification of a more reliable prognosis and appropriate treatment [1–3].A further result is the reduction of overtreatment of those with higher.

Prevalence and prognostic and predictive relevance of PRAME in breast cancer Article (PDF Available) in Breast Cancer Research and Treatment (2) June with 96 Reads. Collectively, the biomarkers and assays presented within this chapter represent great advances in the diagnosis and prognostic assessment of patients with prostate cancer and aid in decision-making for subsequent treatment strategies (reviewed in Table 1).

However, even with this extensive armamentarium there is still improvement to be made in. Cancer can cause many different symptoms. The doctor will order tests to determine if symptoms are caused by cancer or some other problem.

If cancer is diagnosed, the doctor will run tests to determine the stage. Knowing the stage helps the doctor plan treatment and discuss prognosis. Objective To quantify the predictive value of unexpected weight loss (WL) for cancer according to patient’s age, sex, smoking status, and concurrent clinical features (symptoms, signs, and abnormal blood test results).

Design Diagnostic accuracy study. Setting Clinical Practice Research Datalink electronic health records data linked to the National Cancer Registration and Analysis. Risk stratification in oncology suffers from a lack of access to relevant prognostic information, a need for time-consuming manual input of data, a lack of access to comprehensive data, and, in some cases, over-reliance on clinician intuition.

Consider the case of prognostication of a patient with a metastatic, incurable cancer. The terms risk factor, prognostic factor and predictive factor are often imprecisely used.

We defined a prognostic factor as a patient characteristic that identifies subgroups of untreated. NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine.

1 Unit of Molecular Biology and Viral Oncology, Department of Research, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Italy. 2 Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, ORUSA.

3 Immunopathology and Cancer Biomarkers/Bio-Proteomics Facility, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.The incidence of breast cancer is increasing in all Western countries. Due both to a more widespread public education and to early diagnosis by mammography screening programs, the percentage of patients with node-negative breast cancer has gone up to 70%.

Thus, node-negative breast cancer is a major public health problem and, consequently, clinical research in this setting is an expanding field.Prognostic Factors in Cancer, Third Edition examines the prognostic factors associated with each cancer site and provides insight into potential treatments and therapies.

The text is an extension of the International Union Against Cancers (UICC) seminal work, the TNM Classification of Malignant Tumours, and integrates the current focus on prognostics in cancer.